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Imaging the Aging Brain$
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William Jagust and Mark D'Esposito

Print publication date: 2009

Print ISBN-13: 9780195328875

Published to Oxford Scholarship Online: February 2010

DOI: 10.1093/acprof:oso/9780195328875.001.0001

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Genetics and Imaging in Alzheimer’s Disease

Genetics and Imaging in Alzheimer’s Disease

Chapter:
(p.123) 9 Genetics and Imaging in Alzheimer’s Disease
Source:
Imaging the Aging Brain
Author(s):

Susan Y. Bookheimer

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195328875.003.0009

The pathological changes that give rise to Alzheimer's disease (AD) begin years and potentially decades before disease onset. This is well demonstrated using a range of in vivo imaging tools including PET, structural MRI, and functional MRI. In particular, individuals with a genetic risk for AD show similar PET and MRI abnormalities as do Alzheimer's subjects, though to a lesser extent. Studying subjects with a genetic risk for AD prior to the onset of clinically significant memory loss adds to our understanding of the pathological processes leading to AD and may distinguish between those likely to develop the disease and those experiencing normal age-related brain changes. This chapter reviews the major genetic risk factors for AD and discusses the range of imaging abnormalities associated with genetic risk and early manifestations of AD.

Keywords:   aging, Alzheimer's, Apoe, genetics, imaging

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