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Imaging the Aging Brain$
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William Jagust and Mark D'Esposito

Print publication date: 2009

Print ISBN-13: 9780195328875

Published to Oxford Scholarship Online: February 2010

DOI: 10.1093/acprof:oso/9780195328875.001.0001

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White Matter Hyperintensities in Aging and Dementia

White Matter Hyperintensities in Aging and Dementia

Chapter:
(p.273) 17 White Matter Hyperintensities in Aging and Dementia
Source:
Imaging the Aging Brain
Author(s):

Adriane Mayda

Mitsuhiro Yoshita

Charles DeCarli

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195328875.003.0017

Both advancing age and cognitive impairment are associated with increased prevalence of various brain diseases, with Alzheimer's disease (AD) and cerebrovascular disease (CVD) being the most common. Abnormalities of cerebral white matter commonly seen on a magnetic resonance image (MRI) as white matter hyperintensities (WMH) are non-specific, but are increased with aging, CVD, and as a possible consequence of AD. In this chapter, we review current scientific evidence regarding the impact of white matter changes, particularly WMH, on cognition with aging and in the setting of cognitive impairment syndromes such as mild cognitive impairment (MCI) and AD.

Keywords:   Alzheimer's disease, cerebrovascular disease, aging, MCI and MRI

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