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Imaging the Aging Brain$
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William Jagust and Mark D'Esposito

Print publication date: 2009

Print ISBN-13: 9780195328875

Published to Oxford Scholarship Online: February 2010

DOI: 10.1093/acprof:oso/9780195328875.001.0001

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Differential Diagnosis of Dementia Using Functional Neuroimaging

Differential Diagnosis of Dementia Using Functional Neuroimaging

Chapter:
(p.245) 15 Differential Diagnosis of Dementia Using Functional Neuroimaging
Source:
Imaging the Aging Brain
Author(s):

Eric Salmon

Fabienne Collette

Gaëtan Garraux

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195328875.003.0015

Functional neuroimaging in neurodegenerative dementias provides 3D representations of brain activity that are relatively characteristic of the underlying phenotypic distribution of cerebral lesions. They are not specific for a given brain pathology and the heterogeneity of brain diseases must always be considered. However, when methodologies are optimized, the values for sensitivity, specificity, and early diagnostic accuracy approach 80%. A lot of studies have shown that Alzheimer's disease can be distinguished from depression, vascular dementia or frontotemporal dementia, and Lewy body dementia when two techniques are used. General recommendations are to rely on multiple key regions and to combine different neuroimaging techniques to make a differential diagnosis among dementias.

Keywords:   dementia, neuroimaging, brain, diagnostic, accuracy, Alzheimer's disease, frontotemporal

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