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Imaging the Aging Brain$
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William Jagust and Mark D'Esposito

Print publication date: 2009

Print ISBN-13: 9780195328875

Published to Oxford Scholarship Online: February 2010

DOI: 10.1093/acprof:oso/9780195328875.001.0001

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Imaging Cognitive Decline in Aging: Predicting Decline with Structural Imaging

Imaging Cognitive Decline in Aging: Predicting Decline with Structural Imaging

Chapter:
(p.135) 10 Imaging Cognitive Decline in Aging: Predicting Decline with Structural Imaging
Source:
Imaging the Aging Brain
Author(s):

Jeffrey Kaye

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195328875.003.0010

The focus of this chapter is predicting cognitive decline or dementia in normal older people using structural imaging. Key questions addressed include the following: What are the major methods, both clinical and imaging, that may help us to predict decline? What underlying pathologies do structural changes preceding decline suggest are developing in the brain? What is the evidence from structural studies that anatomical changes are present before behavioral ones or precede the diagnosis of mild cognitive impairment or dementia? Does imaging provide information about the pace of future decline? What are the limitations of these studies? Finally, what are the implications of structural imaging outcomes for application to the conduct of treatment studies and future research?

Keywords:   aging, normal brain aging, mild cognitive impairment, dementia, cognition, structural imaging, MRI, neuropathology, clinical prediction

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