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Neurovascular MedicinePursuing Cellular Longevity for Healthy Aging$
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Kenneth Maiese

Print publication date: 2009

Print ISBN-13: 9780195326697

Published to Oxford Scholarship Online: January 2010

DOI: 10.1093/acprof:oso/9780195326697.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 24 February 2020

Mesenchymal Stem Cells and Transdifferentiated Neurons in Cross Talk with the Tissue Microenvironment: Implications for Translational Science

Mesenchymal Stem Cells and Transdifferentiated Neurons in Cross Talk with the Tissue Microenvironment: Implications for Translational Science

Chapter:
(p.215) Chapter 8 Mesenchymal Stem Cells and Transdifferentiated Neurons in Cross Talk with the Tissue Microenvironment: Implications for Translational Science
Source:
Neurovascular Medicine
Author(s):

Katarzyna A. Trzaska

Steven J. Greco

Lisamarie Moore

Pranela Rameshwar

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195326697.003.0008

Stem cells hold vast therapeutic potential in facilitating the treatment of many diseases with high mortality. Central to the advancement in stem cell therapy is a fundamental understanding of the basic biology. Currently, the rapidly growing field of stem cell research sees a dividing line between proponents of embryonic stem cells (ESCs) and those of adult stem cells (ASCs). While ESCs offer a tremendous potential to generate any tissue within the body, there are questions regarding their stability, with the fear of tumorigenesis and ethical concerns. ASCs are found within most organs. The harvesting of a few cells within an organ does not affect the functions of the organ, thereby circumventing the ethical qualms associated with ESCs. However, ASCs raise questions regarding their potential to form varied tissues and their isolation from living organs. Recent reports have shown the ability of ASCs to generate tissues of germ layers other than their own. This cellular plasticity has wrought excitement, as well as skepticism, within the field.

Keywords:   stem cells, embryonic stem cells, adult stem cells, cellular plasticity

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