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Neurovascular MedicinePursuing Cellular Longevity for Healthy Aging$
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Kenneth Maiese

Print publication date: 2009

Print ISBN-13: 9780195326697

Published to Oxford Scholarship Online: January 2010

DOI: 10.1093/acprof:oso/9780195326697.001.0001

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Cross Talk between the Autonomic and Central Nervous Systems: Mechanistic and Therapeutic Considerations for Neuronal, Immune, Vascular, and Somatic-Based Diseases

Cross Talk between the Autonomic and Central Nervous Systems: Mechanistic and Therapeutic Considerations for Neuronal, Immune, Vascular, and Somatic-Based Diseases

Chapter:
(p.101) Chapter 5 Cross Talk between the Autonomic and Central Nervous Systems: Mechanistic and Therapeutic Considerations for Neuronal, Immune, Vascular, and Somatic-Based Diseases
Source:
Neurovascular Medicine
Author(s):

Fuad Lechin

Bertha van der Dijs

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195326697.003.0005

This chapter summarizes anatomical, physiological, pathophysiological, pharmacological, immunological, and some therapeutic information dealing with most types of diseases. Evidence is presented to support the notion that clinical symptoms (cardiovascular, gastrointestinal, respiratory, dermatological, nephrological, rheumatological, hematological, endocrinological, and others) depend on central nervous system (CNS) disorders that project to the peripheral organs throughout the peripheral autonomic nervous system (ANS) and neuroendocrine pathways. In addition, psychological disorders such as depression and psychosis also provoke ANS, hormonal, and immunological disorders that are responsible for different somatic symptoms. The chapter also demonstrates that the adrenal glands are hypoactive during both childhood and senescence. This peripheral ANS profile explains why they are affected by specific pathophysiological disorders that are rarely observed in young adult subjects. This chapter also presents data emanating from the routine assessment of circulating neurotransmitters that showed that diseases are underlain by peripheral nervous system or adrenal sympathetic overactivity.

Keywords:   central nervous system, peripheral autonomic nervous system, depression, psychosis, pathophysiological disorders, adrenal glands, immunological disorders, psychological disorders

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