Jump to ContentJump to Main Navigation
Neurovascular MedicinePursuing Cellular Longevity for Healthy Aging$
Users without a subscription are not able to see the full content.

Kenneth Maiese

Print publication date: 2009

Print ISBN-13: 9780195326697

Published to Oxford Scholarship Online: January 2010

DOI: 10.1093/acprof:oso/9780195326697.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2019. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 20 October 2019

Role of Advanced Glycation End Products, Oxidative Stress, and Inflammation in Diabetic Vascular Complications

Role of Advanced Glycation End Products, Oxidative Stress, and Inflammation in Diabetic Vascular Complications

Chapter:
(p.521) Chapter 21 Role of Advanced Glycation End Products, Oxidative Stress, and Inflammation in Diabetic Vascular Complications
Source:
Neurovascular Medicine
Author(s):

Sho-ichi Yamagishi

Takanori Matsui

Kazuo Nakamura

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195326697.003.0021

Diabetic vascular complication is a leading cause of end-stage renal failure, acquired blindness, a variety of neuropathies, and accelerated atherosclerosis. Recent large prospective clinical studies have shown that intensive glucose control effectively reduces microvascular complications among patients with diabetes. It is now well established that formation and accumulation of advanced glycation end products (AGEs) progress during normal aging, and at an extremely accelerated rate under diabetes, thus being implicated in diabetic vascular complications. Moreover, there is accumulating evidence that AGE and the receptor for AGE (RAGE) interaction elicits oxidative stress generation and subsequently evokes inflammation in vascular wall cells. In addition, digested food-derived AGEs play an important role in the pathogenesis of diabetic vascular complications. These observations suggest that the AGE-RAGE axis and other hyperglycemia-related metabolic derangements are interrelated to each other, being involved in diabetic vascular complications. This chapter discusses the role of AGEs in diabetic retinopathy, diabetic nephropathy, and cardiovascular diseases.

Keywords:   advanced glycation end products, oxidative stress, inflammation, diabetic vascular complications, diabetes, diabetic retinopathy, diabetic nephropathy, cardiovascular diseases

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .