Jump to ContentJump to Main Navigation
Neurovascular MedicinePursuing Cellular Longevity for Healthy Aging$
Users without a subscription are not able to see the full content.

Kenneth Maiese

Print publication date: 2009

Print ISBN-13: 9780195326697

Published to Oxford Scholarship Online: January 2010

DOI: 10.1093/acprof:oso/9780195326697.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 21 February 2020

Neurobiology of Postischemic Recuperation in the Aged Mammalian Brain

Neurobiology of Postischemic Recuperation in the Aged Mammalian Brain

Chapter:
(p.403) Chapter 17 Neurobiology of Postischemic Recuperation in the Aged Mammalian Brain
Source:
Neurovascular Medicine
Author(s):

Aurel Popa-Wagner

Adrian Balseanu

Leon Zagrean

Imtiaz M. Shah

Mario Di Napoli

Henrik Ahlenius

Zaal Kokaia

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195326697.003.0017

Old age is associated with an enhanced susceptibility to stroke and poor recovery from brain injury, but the cellular processes underlying these phenomena are not well understood. Potential mechanism underlying functional recovery after brain ischemia in aged subjects include neuroinflammation, changes in brain plasticity-promoting factors, unregulated expression of neurotoxic factors, or differences in the generation of scar tissue that impedes the formation of new axons and blood vessels in the infarcted region. Studies suggest that behaviorally, aged rats were more severely impaired by ischemia than were young rats and showed diminished functional recovery. Both in old and young rats, the early intense proliferative activity following stroke leads to a precipitous formation of growth-inhibiting scar tissue, a phenomenon amplified by the persistent expression of neurotoxic factors. Recent evidence shows that the human brain can respond to stroke with increased progenitor proliferation in aged patients, opening the possibilities of utilizing this intrinsic attempt for neuroregeneration of the human brain as a potential therapy for ischemic stroke.

Keywords:   ischemic stroke, neurotoxic factors, neuroregeneration, neurobiology, scar tissue, neuroinflammation, brain

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .