This chapter presents an overview of the three chapters (Chapters 2-4) in Part I of the book. The chapters illustrate the important contributions of multilevel integrative analyses to the understanding of these basic mechanisms and to the delineation of the etiology of cardiovascular disease. Each represents a program of research that exemplifies scientific synergism, extending beyond the technical or scientific capacity of a single investigator. Each also uses new and emerging methods and technologies that require multidisciplinary collaborations (e.g., biomedical engineers, cardiologists, biopsychologists, health psychologists).
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