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Textbook of Cancer Epidemiology$
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Hans-Olov Adami, David Hunter, and Dimitrios Trichopoulos

Print publication date: 2008

Print ISBN-13: 9780195311174

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780195311174.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 04 April 2020

Prostate Cancer

Prostate Cancer

(p.517) 20 Prostate Cancer
Textbook of Cancer Epidemiology

Lorelei A. Mucci

Lisa B. Signorello

Hans-Olov Adami

Oxford University Press

Since prostate cancer began to attract more epidemiologic interest in the 1980s, numerous etiologic clues have been identified, and areas are now emerging as promising in the search for causes of prostate cancer. Besides genetic studies, exposures belonging to the broad categories of nutritional and hormonal factors are now being intensively investigated by epidemiologists. These areas are not mutually exclusive since dietary factors may act via hormonal pathways. Among nutritional factors, a protective effect of lycopene, selenium, vitamin E, and perhaps phytoestrogens and fish oil appear particularly promising, although no definite answers have yet emerged. Hormonal influences are also biologically plausible. While studies of steroid hormones, chiefly androgens, have not produced consistent results, a positive association between serum levels of IGF-1 and prostate cancer appears convincing.

Keywords:   genetics, lycopene, selenium, vitamin E, hormones, androgens, IGF-1

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