This chapter discusses the design of neuroimaging experiments. In the design of efficient functional neuroimaging experiments the following needs to be considered: (i) the dynamics of the measured neural variable and (ii) the rate at which this variable can be sampled. MEG studies do not readily accommodate an approach frequently applied in functional magnetic resonance imaging/positron emission tomography (fMRI/PET) studies, in which it is assumed that, for example, when the same type of manual response has been given in two tasks, those tasks can be directly contrasted and the movement effects so removed. MEG data may well reveal that particularly the timing of the neural processes leading to the manual response, and the sensorimotor activation itself, are influenced by the experimental condition. This great advantage (or curse, depending on the situation) of the MEG method has to be kept in mind when designing and piloting new experiments.
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