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Adolescent Psychopathology and the Developing BrainIntegrating Brain and Prevention Science$
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Daniel Romer and Elaine F. Walker

Print publication date: 2007

Print ISBN-13: 9780195306255

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195306255.001.0001

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Maternal Programming of Defensive Responses Through Sustained Effects on Gene Expression

Maternal Programming of Defensive Responses Through Sustained Effects on Gene Expression

Chapter:
(p.148) Chapter 7 Maternal Programming of Defensive Responses Through Sustained Effects on Gene Expression
Source:
Adolescent Psychopathology and the Developing Brain
Author(s):

Michael J. Meaney

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195306255.003.0007

This chapter provides an overview of the long-term effects of early stress on the subsequent development of both physical and mental disorder. It then discusses the role of maternal care during pre- and postnatal periods as an early source of these effects, using research conducted in the laboratory with the rat. The chapter then reviews potential mediators of the effects of maternal behavior on gene expression. The chapter concludes with the questions that remain regarding the effects of early stress on pathology.

Keywords:   stress response, physical disorder, mental disorder, prenatal period, postnatal period, maternal behavior, gene expression

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