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Adolescent Psychopathology and the Developing BrainIntegrating Brain and Prevention Science$
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Daniel Romer and Elaine F. Walker

Print publication date: 2007

Print ISBN-13: 9780195306255

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195306255.001.0001

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Transcriptional Regulation in Schizophrenia

Transcriptional Regulation in Schizophrenia

Chapter:
(p.103) Chapter 5 Transcriptional Regulation in Schizophrenia
Source:
Adolescent Psychopathology and the Developing Brain
Author(s):

Scott E. Hemby

Joann A. O’Connor

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195306255.003.0005

Psychiatric diseases such as schizophrenia and autism spectrum disorders are generally considered to be neurodevelopmental in origin. Dysregulated gene and/or protein expression in the brain of adult schizophrenic patients must be understood in the context of a developmental model. This chapter discusses the basic mechanisms of transcriptional regulation and current knowledge of altered gene expression in schizophrenia focusing on glutamatergic and synaptic mechanisms. The relevance of these gene expression changes to neurodevelopment and other potential mechanisms of regulation in schizophrenia, and ideas about intervention to readjust dysregulated expression are considered.

Keywords:   genetic influence, gene expression, autism, dysregulated expression

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