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Adolescent Psychopathology and the Developing BrainIntegrating Brain and Prevention Science$
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Daniel Romer and Elaine F. Walker

Print publication date: 2007

Print ISBN-13: 9780195306255

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195306255.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2019. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 21 November 2019

Stress-Induced Pathophysiology Within the Schizophrenia Patient Brain

Stress-Induced Pathophysiology Within the Schizophrenia Patient Brain

A Model for the Delayed Onset of Psychosis and Its Circumvention by Anxiolytic Agents

Chapter:
(p.245) Chapter 11 Stress-Induced Pathophysiology Within the Schizophrenia Patient Brain
Source:
Adolescent Psychopathology and the Developing Brain
Author(s):

Anthony A. Grace

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195306255.003.0011

This chapter proposes that the genetic predisposition may lead to deficits in the manner by which the prefrontal cortex (PFC) is capable of modulating responses to stressors, causing the individual to be particularly vulnerable to the pathological changes that eventually culminate in psychosis in adulthood. It presents a potential means to circumvent the transition to psychosis in predisposed individuals by pharmacotherapy of an already-present abnormal response to stress.

Keywords:   psychosis, stress, genetic risk, anti-anxiety medications

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