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Population Genetics, Linguistics, and Culture History in the Southwest Pacific$
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Jonathan S. Friedlaender

Print publication date: 2007

Print ISBN-13: 9780195300307

Published to Oxford Scholarship Online: September 2007

DOI: 10.1093/acprof:oso/9780195300307.001.0001

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Contributions of Population Origins and Gene Flow to the Diversity of Neutral and Malaria Selected Autosomal Genetic Loci of Pacific Island Populations

Contributions of Population Origins and Gene Flow to the Diversity of Neutral and Malaria Selected Autosomal Genetic Loci of Pacific Island Populations

Chapter:
(p.219) 15 Contributions of Population Origins and Gene Flow to the Diversity of Neutral and Malaria Selected Autosomal Genetic Loci of Pacific Island Populations
Source:
Population Genetics, Linguistics, and Culture History in the Southwest Pacific
Author(s):

J. Koji Lum

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195300307.003.0015

This chapter simultaneously deals with the effects of differential selection and with population history. It reviews three studies of either neutral or malaria selected autosomal loci to illustrate the contribution of population origins, gene flow, and disease selection to genetic variation. Neutral genetic diversity within populations generally decreases with distance from Southeast Asia (with the exception of Austronesian speaking populations of Vanuatu), resulting in a clustering of Melanesian populations regardless of linguistic affiliation. The malaria resistant B3Δ27 allele is currently restricted to coastal areas of Papua New Guinea, reflecting its origin with the Lapita colonists and a paucity of gene flow from the coast to inland areas. Within Vanuatu, a North-South gradient of malaria endemicity has resulted in corresponding gradients of resistance and susceptibility conferring alleles. Nearly all of the α-thalassemia alleles of Vanuatu are of inferred New Guinea origin, consistent with an accumulation of alleles from Near Oceania over time.

Keywords:   differential selection, population history, malaria, neutral genetic diversity, malaria resistance, endemicity

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