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Brain DevelopmentNormal Processes and the Effects of Alcohol and Nicotine$
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Michael W. Miller

Print publication date: 2006

Print ISBN-13: 9780195183139

Published to Oxford Scholarship Online: January 2010

DOI: 10.1093/acprof:oso/9780195183139.001.0001

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Neuronal Receptors for Nicotine: Functional Diversity and Developmental Changes

Neuronal Receptors for Nicotine: Functional Diversity and Developmental Changes

Chapter:
(p.341) 21 Neuronal Receptors for Nicotine: Functional Diversity and Developmental Changes
Source:
Brain Development
Author(s):

Huibert D. Mansvelder

Lorna W. Role

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195183139.003.0021

The nicotinic acetylcholine receptor (nAChR) is the principal target-mediator of nicotine from smoking and chewing of tobacco. The effects of nicotine on offspring of pregnant smokers are widespread, ranging from altered neural development to increased susceptibility to addiction in adolescence. These facts underscore the importance of understanding nAChR functions in the prenatal mammalian brain. This chapter discusses the fundamental aspects of acetylcholine (ACh) receptors with which nicotine interacts in the context of potential effects on neural development and plasticity.

Keywords:   neuronal receptors, neural development, nicotine, acetylcholine receptors

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