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Brain DevelopmentNormal Processes and the Effects of Alcohol and Nicotine$
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Michael W. Miller

Print publication date: 2006

Print ISBN-13: 9780195183139

Published to Oxford Scholarship Online: January 2010

DOI: 10.1093/acprof:oso/9780195183139.001.0001

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Cell Proliferation

Cell Proliferation

Chapter:
(p.9) 2 Cell Proliferation
Source:
Brain Development
Author(s):

Bernhard Suter

Pradeep G. Bhide

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195183139.003.0002

Cell proliferation is the earliest step in the protracted process of mammalian brain development. Various genetic and environmental factors modulate the pace of cell proliferation and the number and type of cells produced. This chapter describes the spatiotemporal features of cell proliferation and the effect of neurotransmitters, major constituents of the chemical environment of the developing brain that modulate the process of precursor cell formation. It focuses on three neurotransmitters that are the most abundant in the developing brain: dopamine, γ-aminobutyric acid (GABA), and glutamate. The goal is to present an overview of the organization and activity of precursor cell populations and discuss the potential for modulation of precursor cell activity by neurotransmitters.

Keywords:   cell proliferation, precursor cells, neurotransmitters

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