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Brain DevelopmentNormal Processes and the Effects of Alcohol and Nicotine$
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Michael W. Miller

Print publication date: 2006

Print ISBN-13: 9780195183139

Published to Oxford Scholarship Online: January 2010

DOI: 10.1093/acprof:oso/9780195183139.001.0001

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Mechanisms of Ethanol-Induced Alterations in Neuronal Migration

Mechanisms of Ethanol-Induced Alterations in Neuronal Migration

Chapter:
(p.216) 13 Mechanisms of Ethanol-Induced Alterations in Neuronal Migration
Source:
Brain Development
Author(s):

Julie A. Siegenthaler

Michael W. Miller

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195183139.003.0013

Neuronal migration is the process by which postmitotic neurons translocate from their birthplace in proliferative zones to the appropriate target structure where the neurons integrate into the emerging network. The inability of neurons to properly migrate is one cause of neurological disorders. The cerebral cortex is the brain region most frequently described as exhibiting malformations designated a neuronal migration disorders (NMDs). This chapter shows how NMDs detected in cases of fetal alcohol syndrome are likely caused by ethanol interfering with each phase of the migration.

Keywords:   neuronal migration, cerebral cortex, neuronal migration disorders

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