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The Behavior of the Laboratory RatA Handbook with Tests$
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Ian Q. Whishaw and Bryan Kolb

Print publication date: 2004

Print ISBN-13: 9780195162851

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195162851.001.0001

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Orienting and Placing

Orienting and Placing

Chapter:
(p.129) 12 Orienting and Placing
Source:
The Behavior of the Laboratory Rat
Author(s):

Tim Schallert

Martin T. Woodlee

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195162851.003.0012

This chapter describes behavioral tests that have been useful for examining the potential clinical efficacy of interventions that might be beneficial for neurological disorders. It is important to distinguish whether an intervention promotes brain repair mechanisms, saves cells, enhances motor learning and retraining, or reduces the extent of secondary degeneration of tissue. The chapter includes a subset of sensorimotor tests that are considered to be reliable, sensitive, quantitative, and easy to use in rat neurological models. The tests also cover the range of cellular degeneration typical of focal ischemic injury, nigrostriatal terminal loss, and cervical spinal trauma.

Keywords:   laboratory rats, behavioral tests, neurological disorders, sensorimotor tests, focal ischemic injury, nigrostriatal terminal loss, cervical spinal trauma

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