This chapter describes some of the methodological studies that were conducted as part of the Seattle Longitudinal Study. The discussion mentions the shift from a sampling-without-replacement paradigm to one that involved sampling with replacement, as well as the issue of the aging of tests and results from an investigation designed to determine whether switching to more recently constructed tests would be appropriate in the context of the longitudinal study (1975 collateral study). The possible effect of repeated measurement designs in understating cognitive decline is considered and analyses that adjust for practice effects are presented. The issue of structural equivalence across cohorts, age, time, and gender is also explored.
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