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Helmut Kettenmann and Bruce R. Ransom

Print publication date: 2004

Print ISBN-13: 9780195152227

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195152227.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2019. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 14 December 2019

Response of Microglia to Brain Injury

Response of Microglia to Brain Injury

(p.443) 35 Response of Microglia to Brain Injury

Kazuyuki Nakajima

Shinichi Kohsaka

Oxford University Press

This chapter discusses the response of microglia to brain injuries. Microglia are activated to induce various cellular changes, including morphology, immunohistochemical properties, proliferative activity, chemotactic mobility, biochemical change, secretion, and phagocytosis, in response to the signal(s) produced in the extracellular milieu of the pathological brain. Some putative or plausible signals from injured neurons or activated astrocytes have been predicted based on an acute injury model. In response to these candidate molecules, the microglia produce a specific combination of secretory molecules through a specific signal transduction cascade. Thus, the activated microglia might play different roles according to the type of pathology.

Keywords:   microglial activation, glial cells, brain injuries, astrocytes, cellular changes

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