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Helmut Kettenmann and Bruce R. Ransom

Print publication date: 2004

Print ISBN-13: 9780195152227

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195152227.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2019. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 22 October 2019

Cytokine and Chemokine Receptors and Signaling

Cytokine and Chemokine Receptors and Signaling

(p.146) 11 Cytokine and Chemokine Receptors and Signaling

Duane R. Wesemann

Etty N. Benveniste

Oxford University Press

This chapter discusses the activation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway and the mechanisms that are used to control the magnitude and duration of signaling. It focuses on the suppressor of cytokine signaling (SOCS) family of proteins that act in a negative feedback loop to extinguish signal transduction. It also briefly reviews the other major signalling pathways that are used by tumor necrosis factor (TNF) family members and members of the transforming growth factor (TGF) family. In addition, signaling by chemokines through G-protein-coupled chemokine receptors is described.

Keywords:   Janus kinase, signal transducers, activators, cytokine signaling, chemokine receptor, tumor necrosis factor

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