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Cancer Epidemiology and Prevention$
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David Schottenfeld and Joseph F. Fraumeni

Print publication date: 2006

Print ISBN-13: 9780195149616

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780195149616.001.0001

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Application of Biomarkers in Cancer Epidemiology

Application of Biomarkers in Cancer Epidemiology

Chapter:
(p.70) 6 Application of Biomarkers in Cancer Epidemiology
Source:
Cancer Epidemiology and Prevention
Author(s):

MONTSERRAT GARCÍA-CLOSAS

ROEL VERMEULEN

MARK E. SHERMAN

LEE E. MOORE

MARTYN T. SMITH

NATHANIEL ROTHMAN

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195149616.003.0006

Biomarkers are increasingly being incorporated into epidemiologic studies of cancer etiology, often referred to as molecular epidemiology. This chapter focuses on the use of biomarkers in the context of etiologic research. It begins with a discussion of the development and characterization of biomarkers for use in epidemiologic studies, with a particular emphasis on understanding the components of variance and their impact on estimates of disease risk. It then discusses key issues in the use of exposure, intermediate end points, genetic susceptibility, and tumor biomarkers; and reviews the main epidemiologic study designs that use biomarkers. The chapter concludes with comments on collecting and processing biologic samples for use in molecular epidemiology studies.

Keywords:   cancer etiology, epidemiological studies, cancer risk, molecular epidemiology, variance

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