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A Biologic Approach to Environmental Assessment and Epidemiology$
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Thomas J. Smith and David Kriebel

Print publication date: 2010

Print ISBN-13: 9780195141566

Published to Oxford Scholarship Online: January 2011

DOI: 10.1093/acprof:oso/9780195141566.001.0001

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Irreversible Discrete Disease Processes: Silica and Lung Cancer

Irreversible Discrete Disease Processes: Silica and Lung Cancer

Chapter:
(p.366) 15 Irreversible Discrete Disease Processes: Silica and Lung Cancer
Source:
A Biologic Approach to Environmental Assessment and Epidemiology
Author(s):

Thomas J. Smith

David Kriebel

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195141566.003.0015

The introduction to discrete irreversible processes in Chapter 13 noted that there are two important examples of groups of diseases that follow this pattern: immune sensitization and carcinogenesis. Unfortunately, much less is known about the intermediate steps in sensitization, and few examples of biologically based models have been applied to studies of immune diseases in humans, as was noted. This chapter discusses carcinogenesis, which has been more extensively studied.

Keywords:   lung cancer, carcinogenesis, silica

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