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A Biologic Approach to Environmental Assessment and Epidemiology$
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Thomas J. Smith and David Kriebel

Print publication date: 2010

Print ISBN-13: 9780195141566

Published to Oxford Scholarship Online: January 2011

DOI: 10.1093/acprof:oso/9780195141566.001.0001

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Reversible Discrete Disease Processes: Asthma and Indoor Air, Dermatitis and Metalworking Fluids

Reversible Discrete Disease Processes: Asthma and Indoor Air, Dermatitis and Metalworking Fluids

Chapter:
(p.347) 14 Reversible Discrete Disease Processes: Asthma and Indoor Air, Dermatitis and Metalworking Fluids
Source:
A Biologic Approach to Environmental Assessment and Epidemiology
Author(s):

Thomas J. Smith

David Kriebel

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195141566.003.0014

This chapter illustrates the application of the disease process model approach to discrete reversible disease processes. The process model approach is applied in five steps: (1) identifying and showing the relevance of a tentative process model; (2) identifying one or more markers of the key effect; (3) choosing an etiologic time interval; (4) selecting the hypothetical agent(s) and a measurable marker for exposure; and (5) defining a summary dose metric that represents our hypothesis about the agent and mechanism to be tested in an epidemiologic study.

Keywords:   disease process model, asthma, air pollution, dermatitis, machining fluid exposure, epidemiologic studies

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