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A Biologic Approach to Environmental Assessment and Epidemiology$
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Thomas J. Smith and David Kriebel

Print publication date: 2010

Print ISBN-13: 9780195141566

Published to Oxford Scholarship Online: January 2011

DOI: 10.1093/acprof:oso/9780195141566.001.0001

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Reversible Proportional Disease Processes: Effects of Ammonia and Ozone on Respiratory Symptoms

Reversible Proportional Disease Processes: Effects of Ammonia and Ozone on Respiratory Symptoms

Chapter:
(p.278) 11 Reversible Proportional Disease Processes: Effects of Ammonia and Ozone on Respiratory Symptoms
Source:
A Biologic Approach to Environmental Assessment and Epidemiology
Author(s):

Thomas J. Smith

David Kriebel

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195141566.003.0011

This chapter illustrates the modeling of reversible proportional disease processes using two examples. It first continues to use the simple case of ammonia leading to eye irritation that was presented in Chapters 6 and 10. Then, a more complex case is explored: the respiratory effects of ozone. A historical perspective on ozone dose-response modeling is useful because the literature followed a path of increasingly complex and biologically relevant models as more and more data were obtained. Laying out this history illustrates the limitations of the empirical approach and the advantages of biologically based models.

Keywords:   exposure assessment, epidemiologic study, ammonia, respiratory effects, ozone, dose-response modeling

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