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NeuroepidemiologyFrom principles to practice$
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Lorene M. Nelson, Caroline M. Tanner, Stephen Van Den Eeden, and Valarie M. McGuire

Print publication date: 2004

Print ISBN-13: 9780195133790

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780195133790.001.0001

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Genetic Epidemiology of Neurologic Disease

Genetic Epidemiology of Neurologic Disease

(p.85) 4 Genetic Epidemiology of Neurologic Disease

Lorene M. Nelson

Caroline M. Tanner

Stephen K. Van Den Eeden

Valerie M. McGuire

Oxford University Press

This chapter begins with a discussion of Mendelian versus complex (non-Mendelian) neurological disorders, followed by an overview of the structure of DNA and the molecular basis of disease. It considers the methods of genetic epidemiology, differentiating family-based studies from population-based studies of unaffected individuals. The options for genetic epidemiology study designs are presented, with a discussion of strengths and limitations of each approach. Recent technological developments are discussed, as are the important ethical and social implications of genetic epidemiologic research in the study of neurological disorders.

Keywords:   genetic epidemiology, Hardy-Weinberg equilibrium, Mendelian disorders, molecular epidemiology, family-based studies, population-based studies, ethical issues, social issues

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