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Issues in Palliative Care Research$
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Russell K. Portenoy and Eduardo Bruera

Print publication date: 2003

Print ISBN-13: 9780195130652

Published to Oxford Scholarship Online: November 2011

DOI: 10.1093/acprof:oso/9780195130652.001.0001

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Palliative Care Research in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome: Clinical Trials of Symptomatic Therapies

Palliative Care Research in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome: Clinical Trials of Symptomatic Therapies

Chapter:
(p.371) 24 Palliative Care Research in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome: Clinical Trials of Symptomatic Therapies
Source:
Issues in Palliative Care Research
Author(s):

Russell K. Portenoy

Eduardo Bruera

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195130652.003.0024

With the widespread introduction of highly active antiretroviral therapies (HAARTs), mortality rates among patients with advanced human immunodeficiency virus (HIV) disease have declined dramatically. While death rates from AIDS have been halved by the introduction of HAART, AIDS remains a disease without a definitive treatment. This chapter reviews the major areas of research in AIDS palliative care and begins with research addressing the important issues of pain and fatigue. It discusses studies dealing with the major neuropsychiatric syndromes of delirium and dementia. This is followed by an overview of the research focusing on major psychiatric illnesses, including depression, anxiety, and psychosis. It also describes intervention trials for endocrinopathies and AIDS-related cachexia. The chapter concludes with a brief look at two complex end-of-life issues: physician-assisted suicide and desire for death in the terminally ill.

Keywords:   HIV, AIDS, pain, depression, highly active antiretroviral therapies, psychiatric illnesses, fatigue, dementia, assisted suicide

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