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Issues in Palliative Care Research$
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Russell K. Portenoy and Eduardo Bruera

Print publication date: 2003

Print ISBN-13: 9780195130652

Published to Oxford Scholarship Online: November 2011

DOI: 10.1093/acprof:oso/9780195130652.001.0001

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Methodological Issues in the Design of Analgesic Clinical Trials

Methodological Issues in the Design of Analgesic Clinical Trials

Chapter:
(p.3) 1 Methodological Issues in the Design of Analgesic Clinical Trials
Source:
Issues in Palliative Care Research
Author(s):

Russell K. Portenoy

Eduardo Bruera

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195130652.003.0001

This chapter discusses some of the firm conclusions from the experience of analgesic research and highlights areas of analgesic trial methodology that have had relatively little exploration, particularly repeated-dose studies in chronic pain, where an ongoing dialogue among symptom researchers might move all of these fields ahead. Several generations of analgesic researchers have come to a consensus on approaches to single-dose analgesic studies. Because the studies of other symptoms may share some of the same challenges, palliative care researchers may benefit from a familiarity with the analgesic study design literature. However, many clinical research problems with pain and other symptoms have received rather little study, including optimizing the sensitivity of symptom-based measures, combination studies, and the choice of control groups in repeated-dose studies. The solution to many of these problems may be facilitated by frequent discussions among clinical researchers working in different symptom areas.

Keywords:   analgesic research, chronic pain, palliative care, symptom researchers, combination studies, repeated-dose studies

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