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Genetics and Public Health in the 21st CenturyUsing Genetic Information to Improve Health and Prevent Disease$
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Muin J. Khoury, Wylie Burke, and Elizabeth Thomson

Print publication date: 2000

Print ISBN-13: 9780195128307

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780195128307.001.0001

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Applying genetic strategies to prevent atherosclerosis

Applying genetic strategies to prevent atherosclerosis

(p.463) 24 Applying genetic strategies to prevent atherosclerosis
Genetics and Public Health in the 21st Century

Roger R. Williams

Paul N. Hopkins

Lily L. Wu

Steven C. Hunt

Oxford University Press

Atherosclerotic disease of coronary and cerebral arteries accounts for almost half of all deaths in the United States each year. Heart attacks and strokes are often attributable to inherited predisposition, especially when they occur at a relatively early age. Researchers are accumulating information regarding the role of genetics in influencing the risk factors for atherosclerosis in several major categories, including lipids and lipoproteins (LDL HDL and VLDL cholesterol; Lp(a); triglycerides; apo ALAII, and B; apo E genotypes); glucose and insulin metabolism (diabetes, glucose intolerance, and insulin resistance); prothrombotic factors (fibrinogen, plasminogen activator inhibitor-1, factor VII coagulant activity, homocysteine); and hypertension. This chapter discusses the basic approaches for evaluating and addressing heritable factors for atherosclerosis.

Keywords:   atherosclerotic disease, heart disease, public health, genetic factors, strokes

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