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Molecular and Cellular Approaches to Neural Development$
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W. Maxwell Cowan, Thomas M. Jessell, and S. Lawrence Zipursky

Print publication date: 1998

Print ISBN-13: 9780195111668

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195111668.001.0001

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The role of Hox genes in hindbrain development

The role of Hox genes in hindbrain development

Chapter:
(p.334) 9 The role of Hox genes in hindbrain development
Source:
Molecular and Cellular Approaches to Neural Development
Author(s):

Mario R. Capecchi

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195111668.003.0009

This chapter discusses current understanding of hindbrain development with particular emphasis on the roles of Hox genes in mediating this process. The chapter is divided into three sections. The first section explores the properties of rhombomeres that influence how the neuronal architecture of the hindbrain is formed. The second examines the organization, expression patterns, and genetic function of Hox genes. The positional cues for patterning the head and neck appear to depend on the underlying embryonic organization of the central nervous system. The third section focuses on the neural crest, which is the conduit for transferring this positional information.

Keywords:   rhombomeres, Hox genes, neural crest, brain development, hindbrain

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