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Molecular and Cellular Approaches to Neural Development$
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W. Maxwell Cowan, Thomas M. Jessell, and S. Lawrence Zipursky

Print publication date: 1998

Print ISBN-13: 9780195111668

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195111668.001.0001

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Inductive signals and the assignment of cell fate in the spinal cord and hindbrain

Inductive signals and the assignment of cell fate in the spinal cord and hindbrain

An axial coordinate system for neural patterning

Chapter:
(p.290) 8 Inductive signals and the assignment of cell fate in the spinal cord and hindbrain
Source:
Molecular and Cellular Approaches to Neural Development
Author(s):

Thomas M. Jessell

Andrew Lumsden

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195111668.003.0008

Recent studies of the molecular mechanisms that control the identity and pattern of neural cell types generated in vertebrate embryos have focused on three main issues: (i) defining the source and identity of signals controlling the fate of nearby cells; (ii) defining cell-intrinsic factors that commit neural cells to specific fates; and (iii) determining how intrinsic regulatory proteins direct the expression of the sensory machinery required in and on the growth cone for recognition of local guidance cues. This chapter focuses on the patterning mechanisms implicated in the generation of distinct cell types at caudal levels of the neural tubes that give rise to the segmentally organized structure of the spinal cord and hind brain.

Keywords:   spinal cord, hindbrain, neural cell types, molecular mechanisms, neural tubes

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