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Molecular and Cellular Approaches to Neural Development$
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W. Maxwell Cowan, Thomas M. Jessell, and S. Lawrence Zipursky

Print publication date: 1998

Print ISBN-13: 9780195111668

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195111668.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2019. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 18 September 2019

The determination of the neuronal phenotype

The determination of the neuronal phenotype

Chapter:
(p.26) 2 The determination of the neuronal phenotype
Source:
Molecular and Cellular Approaches to Neural Development
Author(s):

David J. Anderson

Yuh Nung Jan

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195111668.003.0002

This chapter addresses the following questions: What are the key regulatory genes that specify a neuronal fate and a particular neuronal identity? What do they do? How are they controlled? In addition of identifying key regulatory genes, an attempt is also made to address the “logic” of neuronal determination and differentiation. It argues that current knowledge of the details of the underlying molecular genetic circuitry that determines the identity of any kind of neuron, in any organism, remains sketchy. However, a few general principles are beginning to emerge, particularly the idea that neuronal identity is implemented in series and in parallel in a collection of subprograms, rather than one coordinately active “master” program.

Keywords:   Drosophila, neuronal determination, neuronal differentiation, regulatroy genes, subprograms

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