Jump to ContentJump to Main Navigation
The Hippocampus Book$
Users without a subscription are not able to see the full content.

Per Andersen, Richard Morris, David Amaral, Tim Bliss, and John O'Keefe

Print publication date: 2006

Print ISBN-13: 9780195100273

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195100273.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2019. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 18 September 2019

Synaptic Plasticity in the Hippocampus

Synaptic Plasticity in the Hippocampus

Chapter:
(p.343) 10 Synaptic Plasticity in the Hippocampus
Source:
The Hippocampus Book
Author(s):

Bliss Tim

Collingridge Graham

Morris Richard

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195100273.003.0010

The chapter opens with a brief historical account of the first two decades of research into about long-term potentiation (LTP) and long-term depression (LTD). Section 10.2 discusses the various short-term forms of plasticity that hippocampal synapses share with most if not all synapses: paired-pulse facilitation and depression and post-tetanic potentiation. Sections, 10.3 and 10.4 focus on the mechanisms supporting the induction and expression of N-methyl-D-aspartate (NMDA) receptor-dependent LTP. Section 10.5 discusses mossy fiber LTP. Section 10.6 surveys neuromodulatory systems that affect LTP, such as the cholinergic input, catecholamines, and neurotrophins. Section 10.7 explores the world of long-term depression, and the “depotentiation” of LTP. Section 10.8 examines the evidence for LTP and LTD at excitatory synapses onto interneurons and inhibitory synapses made by interneurons. Section 10.9 turns to synaptic plasticity in development, and in the aging animal, and discusses how LTP and LTD are affected in animal models of cognitive decline. Finally, section 10.10 surveys and assesses the evidence relating to the question: Why do hippocampal synapses display these striking forms of plasticity, and does the intact animal exploit them to acquire and store memories?

Keywords:   long-term potentiation, long-term depression, hippocampal synapses, N-methyl-D-aspartate, plasticity, post-tetanic potentiation

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .