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The Cortical Neuron$
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Michael J. Gutnick and Istvan Mody

Print publication date: 1995

Print ISBN-13: 9780195083309

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780195083309.001.0001

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Neurotransmitter Signaling Before the Birth of Neurons

Neurotransmitter Signaling Before the Birth of Neurons

Chapter:
(p.197) Chapter 14 Neurotransmitter Signaling Before the Birth of Neurons
Source:
The Cortical Neuron
Author(s):

Jo J. Loturco

Arnold R. Kriegstein

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195083309.003.0014

Recent advances in cellular physiological techniques, particularly the development of in situ whole-cell patch-clamp recording, have permitted detailed physiological and pharmacological studies of proliferating cells in the ventricular and subventricular zones of embryonic neocortex. The results are beginning to shed light on the kinds of signals and cellular interactions that may underlie the regulation of cell-cycle events and gene expression in cortical progenitor cells. This chapter discusses the following topics: gap-junction channels provide an avenue for intracellular communication among cortical progenitors; uncoupling blocks DNA synthesis; the principal excitatory and inhibitory amino acid receptors are expressed before neuronal differentiation; cell-cycle events in the embryonic cortex are influenced by GABA and glutamate; GABA depolarizes ventricular zone cells because of high intracellular chloride concentration maintained by a chloride exchange pump; depolarization mediates the DNA synthesis inhibition induced by GABA and glutamate.

Keywords:   neocortex, gap junction, cortical progenitor, amino acid, GABA, glutamate

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