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Receptor and Ion-Channel TraffickingCell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels$
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Stephen J. Moss and Jeremy Henley

Print publication date: 2002

Print ISBN-13: 9780192632241

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780192632241.001.0001

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GABAA and GABAC receptors: regulation of assembly, localization, clustering and turnover

GABAA and GABAC receptors: regulation of assembly, localization, clustering and turnover

Chapter:
(p.192) Chapter 9 GABAA and GABAC receptors: regulation of assembly, localization, clustering and turnover
Source:
Receptor and Ion-Channel Trafficking
Author(s):

Bernhard Lüscher

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780192632241.003.0009

The neurotransmitter γ-aminobutyric acid (GABA) confers neural inhibition in the central nervous system primarily by acting at GABA-gated chloride channels named GABAA and GABAc receptors. Structurally and functionally distinct receptor subtypes are assembled from multiple homologous subunits. Receptor heterogeneity is, however, limited by only partial overlap in the expression pattern of the different subunits and by the rules that govern receptor assembly. GABAc receptors are homo- or heteromers composed of ρl–3 subunits. Formation of GABAA receptors involves initial assembly of α and β subunits followed by the addition of a third type of subunit, most commonly the γ2 subunit.

Keywords:   GABAc receptors, GABAA receptors, receptor homogeneity, neural inhibition, GABA, receptor subtypes

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