Jump to ContentJump to Main Navigation
Receptor and Ion-Channel TraffickingCell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels$
Users without a subscription are not able to see the full content.

Stephen J. Moss and Jeremy Henley

Print publication date: 2002

Print ISBN-13: 9780192632241

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780192632241.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2019. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 15 September 2019

NMDA receptor targeting

NMDA receptor targeting

Chapter:
(p.156) Chapter 7 NMDA receptor targeting
Source:
Receptor and Ion-Channel Trafficking
Author(s):

Heike Hering

Morgan Sheng

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780192632241.003.0007

The N-methyl-d-aspartate (NMDA) class of ionotropic glutamate receptor has received special attention because it is critical for many forms of activity-dependent synaptic plasticity, some of which may underlie learning and memory in the brain. For instance, the blockade of NMDA receptors prevents long-term potention (LTP) in the hippocampus and impairs learning. NMDA receptor stimulation allows an influx of calcium ions into the postsynaptic cell and the activation of multiple intracellular signaling pathways. The signal transduction events initiated by NMDA receptor stimulation involve protein kinases, phosphatases, small GTPases and other enzymes, leading to changes in the cytoskeleton, membrane excitability, cell adhesion, transcription, and translation and other adaptive responses in the postsynaptic cell.

Keywords:   NMDA receptor, protein kinases, protein phosphatases, GTPases, synaptic plasticity, learning, memory, LTP, postsynaptic cell, intracellular signaling pathways

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .