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Receptor and Ion-Channel TraffickingCell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels$
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Stephen J. Moss and Jeremy Henley

Print publication date: 2002

Print ISBN-13: 9780192632241

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780192632241.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2019. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 16 September 2019

Targeting of acetylcholine receptors to the postsynaptic endplate of the nerve–muscle synapse

Targeting of acetylcholine receptors to the postsynaptic endplate of the nerve–muscle synapse

Chapter:
(p.88) (p.89) Chapter 4 Targeting of acetylcholine receptors to the postsynaptic endplate of the nerve–muscle synapse
Source:
Receptor and Ion-Channel Trafficking
Author(s):

Sheridan L. Swope

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780192632241.003.0004

Synaptic transmission is dependent on the precise juxtaposition of the presynaptic nerve terminal with a localized high density of neurotransmitter receptors in the postsynaptic cell. For decades, the neuromuscular junction (NMJ) has served as an excellent system to study the molecular biology, biochemistry, and cell biology of synapse formation and function. The enrichment of synaptic components in the electric organs of Torpedo californica (TEO) has provided a system to identify, purify, clone, and characterize the function of the molecular components at the NMJ. The nicotinic acetylcholine receptor (nAChR) is the ligand-gated ion channel that mediates rapid depolarization of the postsynaptic membrane at the NMJ.

Keywords:   presynaptic nerve terminal, synaptic transmission, acetylcholine receptors, neuromuscular junction, Torpedo californica

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