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Antenatal and Neonatal Screening$
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Nicholas Wald and Ian Leck

Print publication date: 2000

Print ISBN-13: 9780192628268

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780192628268.001.0001

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Tests using multiple markers

Tests using multiple markers

Chapter:
(p.23) 2 Tests using multiple markers
Source:
Antenatal and Neonatal Screening
Author(s):

Nicholas Wald

Allan Hackshaw

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780192628268.003.0002

This chapter describes the methodology behind screening using multiple markers together in a single test. The method is based on estimating an individual's risk of having the disorder being screened for. This is the most efficient method for screening with multiple markers because it maximizes the detection rate for a given false-positive rate. Risk replaces component markers as the screening variable.

Keywords:   screening tests, diagnostic tests, multivariate screening, multiple markers, detection rate, false-positive rate

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