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Design Concepts in Nutritional Epidemiology$
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Barrie M. Margetts and Michael Nelson

Print publication date: 1997

Print ISBN-13: 9780192627391

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780192627391.001.0001

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7. Biochemical markers of nutrient intake

7. Biochemical markers of nutrient intake

(p.170) 7. Biochemical markers of nutrient intake
Design Concepts in Nutritional Epidemiology

Chris J. Bates

David I. Thurnham

Sheila A. Bingham

Barrie M. Margetts

Michael Nelson

Oxford University Press

This chapter takes a look at the utility of biochemical measurements in different body tissues for estimating dietary exposures (as opposed to the determination of nutritional status). Validity (accuracy) and reproducibility (precision) are defined in relation to biomarkers in light of natural variations in physiological levels within and between individuals. Definitions are given of measures of nutrients in blood, urine, and other tissues, and compartments (e.g., hair, saliva, adipose tissue, finger nails, toe nails), and the feasibility of predicting intake from each measure. The chapter then describes relevant measures, nutrient by nutrient, for vitamins, minerals, lipids, protein, and energy, and the problems relating to dietary fibre.

Keywords:   biomarkers, intake, validity, reproducibility, physiological variation, strengths, weaknesses

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