Jump to ContentJump to Main Navigation
Design Concepts in Nutritional Epidemiology$
Users without a subscription are not able to see the full content.

Barrie M. Margetts and Michael Nelson

Print publication date: 1997

Print ISBN-13: 9780192627391

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780192627391.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2019. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a monograph in OSO for personal use (for details see www.oxfordscholarship.com/page/privacy-policy).date: 24 June 2019

11. Gene–nutrient interactions in nutritional epidemiology

11. Gene–nutrient interactions in nutritional epidemiology

(p.312) 11. Gene–nutrient interactions in nutritional epidemiology
Design Concepts in Nutritional Epidemiology

Lenore Kohlmeier

David DeMarini

Walter Piegorsch

Oxford University Press

There is increasing evidence that the ways in which nutrients are handled metabolically is, to a greater or lesser extent, under genetic control. Equally, nutrient (and non-nutrient) intakes affect the expression of genetic predispositions. These complex interactions (nutrient regulation of gene transcription, food-induced DNA damage, phytochemical enhancement or protection of DNA integrity, genetic susceptibility to nutrition-related diseases) increasingly shed light on epidemiological relationships between diet and health and disease. This chapter considers design and analytical implications for understanding gene-nutrient interactions, including specific statistical models. It concludes with a discussion of ethical issues, and an appendix for sample size determination in relation to the determination of genetic characteristics in nutritional epidemiological studies.

Keywords:   genetics, gene-nutrient interactions, DNA damage, DNA integrity, sample size, ethics

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .