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Migraine: A Spectrum of Ideas$
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Merton Sandler and Geralyn M. Collins

Print publication date: 1990

Print ISBN-13: 9780192618108

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780192618108.001.0001

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Migraine pathogenesis examined with contemporary techniques for analysing brain function

Migraine pathogenesis examined with contemporary techniques for analysing brain function

Chapter:
(p.105) 9. Migraine pathogenesis examined with contemporary techniques for analysing brain function
Source:
Migraine: A Spectrum of Ideas
Author(s):

K.M.A. Welch

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780192618108.003.0009

Progress in the understanding of migraine pathogenesis has been hampered by the unavailability of animal models for this disorder. Thus, there has been limited study of the human condition itself. Until recently, direct examination of brain function could not be performed without hazard to the patient. Now, with techniques such as positron emission tomography, nuclear magnetic resonance spectroscopy, 133Xe-inhalation cerebral blood flow (CBF), and magnetoencephalography we can derive insights into central mechanisms of the attack. This chapter reviews the evidence obtained by these non-invasive techniques in the context of a conceptual mechanism for migraine — that is, that the attack is due to an abnormality of the normally finely tuned interaction between neuronal and vascular elements of the central nervous system (CNS).

Keywords:   migraine pathogenesis, brain function, human condition, positron emission tomography, regional cerebral blood flow, xenon-133

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