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Migraine: A Spectrum of Ideas$
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Merton Sandler and Geralyn M. Collins

Print publication date: 1990

Print ISBN-13: 9780192618108

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780192618108.001.0001

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Genetic epidemiology of migraine

Genetic epidemiology of migraine

Chapter:
(p.40) 4. Genetic epidemiology of migraine
Source:
Migraine: A Spectrum of Ideas
Author(s):

Kathleen R. Merikangas

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780192618108.003.0004

The hereditary nature of migraine has been reported consistently since it was first noted by S. A. Tissot in the 18th century. Indeed, the association between migraine and family history was believed to be so strong that it was included as a criterion for diagnosing migraine in the definition adopted by the Ad Hoc Committee on the classification of headache in 1962. The most recent catalogue of Mendelian diseases in humans lists migraine as an autosomal dominant condition. Nevertheless, both the role of genetic factors in the pathogenesis of migraine and its mode of inheritance continue to be elusive.

Keywords:   family history, migraine, headache, genetic epidemiology, autosomal dominant condition, pathogenesis

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