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Migraine: A Spectrum of Ideas$
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Merton Sandler and Geralyn M. Collins

Print publication date: 1990

Print ISBN-13: 9780192618108

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780192618108.001.0001

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The biochemical basis of migraine predisposition

The biochemical basis of migraine predisposition

Chapter:
(p.228) 19. The biochemical basis of migraine predisposition
Source:
Migraine: A Spectrum of Ideas
Author(s):

Vivette Glover

Merton Sandler

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780192618108.003.0019

This chapter discusses some aspects of the biochemistry of migraine predisposition, and indicate how some of the initiating factors may interact with the central monoamine systems. Professor Lance and others have discussed persuasively how these centres (particularly the raphe nuclei and locus coeruleus) may be involved in the generation of a migraine attack. It is likely that the more we understand about individual vulnerability, the more we may be able to tailor specific treatment to particular patients.

Keywords:   migraine predisposition, biochemistry, monoamine systems, raphe nuclei, migraine attack, locus coeruleus

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