Jump to ContentJump to Main Navigation
Migraine: A Spectrum of Ideas$
Users without a subscription are not able to see the full content.

Merton Sandler and Geralyn M. Collins

Print publication date: 1990

Print ISBN-13: 9780192618108

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780192618108.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2019. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 20 August 2019

Novel agents affecting enkephalinergic and histaminergic transmissions in brain

Novel agents affecting enkephalinergic and histaminergic transmissions in brain

Chapter:
(p.218) 18. Novel agents affecting enkephalinergic and histaminergic transmissions in brain
Source:
Migraine: A Spectrum of Ideas
Author(s):

J.C. Schwartz

B. Giros

C. Gros

C. Llorens-Cortes

J.M. Arrang

M. Garbarg

H. Pollard

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780192618108.003.0018

Progress in cephalalgia therapy may be anticipated from the development of novel classes of drugs that affect either the transmission of pain messages or the control of vascular mechanisms in the brain. A valuable strategy for achieving such an aim consists in identifying new molecular targets that are critically involved in neurotransmitter metabolism or actions. This line has been followed in recent years in our laboratory to identify the mechanisms responsible for opioid peptide inactivation, and for the control of histamine release from its cerebral neurones. In both cases, relevant molecular targets were identified — that is, two ‘neuropeptidases’ responsible for enkephalin breakdown, and the H3 autoreceptor responsible for the control of histamine synthesis and release. Agents able to interact selectively and potently with these various targets have been rationally designed to help us to study the corresponding control mechanisms. These agents may constitute new drugs to be used in human therapeutics.

Keywords:   enkephalinergic transmissions, histaminergic transmissions, H3 autoreceptor, pain messages, vascular mechanisms, neuropeptidases

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .