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Migraine: A Spectrum of Ideas$
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Merton Sandler and Geralyn M. Collins

Print publication date: 1990

Print ISBN-13: 9780192618108

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780192618108.001.0001

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Peptidergic mechanisms in human intracranial and extracranial arteries

Peptidergic mechanisms in human intracranial and extracranial arteries

Chapter:
(p.207) 17. Peptidergic mechanisms in human intracranial and extracranial arteries
Source:
Migraine: A Spectrum of Ideas
Author(s):

Lars Edvinsson

Inger Jansen

Rolf Uddman

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780192618108.003.0017

Migraine attacks are conventionally thought to involve a dysfunction in the regulation of tone in intra- and extracranial blood vessels. A number of agents have been suggested as responsible for the altered vasomotor responses seen in conjunction with migraine attacks. Previous histochemical studies have shown that human cerebral arteries are surrounded by adrenergic and cholinergic nerve fibres. In addition, peptide-containing nerve fibres, such as neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), substance P (SP), and calcitonin gene-related peptide (CGRP), have been observed around the cerebral blood vessels of laboratory animals. Few studies have been carried out on human temporal and cerebral arteries, but none on meningeal arteries. This chapter examines the distribution of NPY-, VIP-, SP- and CGRP-immunoreactive fibres around the three types of human cranial arteries and compared the pharmacological effects of the perivascularly located neuropeptides on arterial segments.

Keywords:   extracranial blood vessels, migraine attack, vasoactive intestinal peptide, neuropeptide Y, calcitonin gene-related peptide, neuropeptides

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