- Title Pages
- 1. Introduction
- 2. The nature of migraine: do we need to invoke slow neurochemical processes?
- 3. Contribution of experimental studies to understanding the pathophysiology of migraine
- 4. Genetic epidemiology of migraine
- 5. A possible role of endothelial vasorelaxants in the pathogenesis of migraine
- 6. A classification of peripheral analgesics based upon their mode of action
- 7. Vasomotor functions of trigeminovascular fibres: inferences from lesion studies
- 8. Regional cerebral blood flow in migraine
- 9. Migraine pathogenesis examined with contemporary techniques for analysing brain function
- 10. The superior pericarotid cavernous sinus plexus and cluster headaches
- 11. 5-HT in migraine: evidence from 5-HT receptor antagonists for a neuronal aetiology
- 12. 5-HT in migraine: evidence from 5-HT<sub>1</sub>-like receptor agonists for a vascular aetiology
- 13. Behavioural effects of <i>m</i>-chlorophenylpiperazine (<i>m</i>-CPP), a reported migraine precipitant
- 14. 5-HT receptors and migraine
- 15. Is there still a case for the shunt hypothesis in migraine?
- 16. General discussion I
- 17. Peptidergic mechanisms in human intracranial and extracranial arteries
- 18. Novel agents affecting enkephalinergic and histaminergic transmissions in brain
- 19. The biochemical basis of migraine predisposition
- 20. Depression and migraine
- 21. Pain, headache, and depression: a discussion
- 22. A note on the role of platelets in migraine: a personal view
- 23. Differential abnormalities in signal transduction in migraine and cluster headache
- 24. The current status of migraine therapy
- 25. Treatment: where are we going?
- 26. General discussion II
- 27. The neurovascular basis of migraine: some concluding thoughts
General discussion I
General discussion I
- (p.200) 16. General discussion I
- Migraine: A Spectrum of Ideas
Geralyn M. Collins
- Oxford University Press
This chapter discusses 5-HT uptake, platelets, and migraine. 5-HT (5-hydroxytryptamine; serotonin) has been studied in relation to migraine for about twenty years, but in relation to depression for about thirty years. The relationship between migraine and depression is fascinating. The prodromal symptoms of migraine are very much like those of an affective disorder. Over the last ten years 5-HT uptake by the platelets has been studied with interest. The platelet is readily accessible for study, and some of its transport systems may have something in common with those in the central nervous system.
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