- Title Pages
- 1. Introduction
- 2. The nature of migraine: do we need to invoke slow neurochemical processes?
- 3. Contribution of experimental studies to understanding the pathophysiology of migraine
- 4. Genetic epidemiology of migraine
- 5. A possible role of endothelial vasorelaxants in the pathogenesis of migraine
- 6. A classification of peripheral analgesics based upon their mode of action
- 7. Vasomotor functions of trigeminovascular fibres: inferences from lesion studies
- 8. Regional cerebral blood flow in migraine
- 9. Migraine pathogenesis examined with contemporary techniques for analysing brain function
- 10. The superior pericarotid cavernous sinus plexus and cluster headaches
- 11. 5-HT in migraine: evidence from 5-HT receptor antagonists for a neuronal aetiology
- 12. 5-HT in migraine: evidence from 5-HT<sub>1</sub>-like receptor agonists for a vascular aetiology
- 13. Behavioural effects of <i>m</i>-chlorophenylpiperazine (<i>m</i>-CPP), a reported migraine precipitant
- 14. 5-HT receptors and migraine
- 15. Is there still a case for the shunt hypothesis in migraine?
- 16. General discussion I
- 17. Peptidergic mechanisms in human intracranial and extracranial arteries
- 18. Novel agents affecting enkephalinergic and histaminergic transmissions in brain
- 19. The biochemical basis of migraine predisposition
- 20. Depression and migraine
- 21. Pain, headache, and depression: a discussion
- 22. A note on the role of platelets in migraine: a personal view
- 23. Differential abnormalities in signal transduction in migraine and cluster headache
- 24. The current status of migraine therapy
- 25. Treatment: where are we going?
- 26. General discussion II
- 27. The neurovascular basis of migraine: some concluding thoughts
5-HT receptors and migraine
5-HT receptors and migraine
- (p.182) 14. 5-HT receptors and migraine
- Migraine: A Spectrum of Ideas
Pramod R. Saxena
- Oxford University Press
Migraine is a vascular headache but its pathophysiology is complex and multifactorial. Of the many pathophysiological factors that are implicated in migraine, changes in the metabolism of 5-hydroxytryptamine (5-HT) are the best documented. During the headache phase of migraine, urinary excretion of 5-hydroxyindoleacetic acid increases, whereas the blood 5-HT concentration decreases. Furthermore, in migraine patients reserpine precipitates a headache that can be alleviated by 5-HT. In the light of recent developments in the characterization and classification of the receptors for 5-HT, this article aims to discuss the relationship between the neural and cephalovascular 5-HT receptors and the antimigraine action of drugs.
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