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Migraine: A Spectrum of Ideas$
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Merton Sandler and Geralyn M. Collins

Print publication date: 1990

Print ISBN-13: 9780192618108

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780192618108.001.0001

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5-HT receptors and migraine

5-HT receptors and migraine

Chapter:
(p.182) 14. 5-HT receptors and migraine
Source:
Migraine: A Spectrum of Ideas
Author(s):

Pramod R. Saxena

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780192618108.003.0014

Migraine is a vascular headache but its pathophysiology is complex and multifactorial. Of the many pathophysiological factors that are implicated in migraine, changes in the metabolism of 5-hydroxytryptamine (5-HT) are the best documented. During the headache phase of migraine, urinary excretion of 5-hydroxyindoleacetic acid increases, whereas the blood 5-HT concentration decreases. Furthermore, in migraine patients reserpine precipitates a headache that can be alleviated by 5-HT. In the light of recent developments in the characterization and classification of the receptors for 5-HT, this article aims to discuss the relationship between the neural and cephalovascular 5-HT receptors and the antimigraine action of drugs.

Keywords:   vascular headache, 5-hydroxytryptamine, pathophysiology, urinary excretion, 5-HT receptors, action of drugs

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