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Migraine: A Spectrum of Ideas$
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Merton Sandler and Geralyn M. Collins

Print publication date: 1990

Print ISBN-13: 9780192618108

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780192618108.001.0001

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5-HT in migraine: evidence from 5-HT1-like receptor agonists for a vascular aetiology

5-HT in migraine: evidence from 5-HT1-like receptor agonists for a vascular aetiology

Chapter:
(p.147) 12. 5-HT in migraine: evidence from 5-HT1-like receptor agonists for a vascular aetiology
Source:
Migraine: A Spectrum of Ideas
Author(s):

P.P.A. Humphrey

W. Feniuk

M.J. Perren

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780192618108.003.0012

Regardless of the many considerations, GR43175 has been shown to be effective when administered subcutaneously and orally as well as when administered intravenously in the treatment of acute migraine. It is now in phase III clinical trials and promises to provide a major breakthrough in migraine therapy. Importantly, further studies on its clinical mechanism of action are in progress and they will, it is hoped, be invaluable in elucidating the pathogenesis of migraine and vascular headache.

Keywords:   vascular aetiology, acute migraine, treatment of migraine, clinical trials, vascular headache, pathogenesis

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