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Lainie Friedman Ross

Print publication date: 2006

Print ISBN-13: 9780199273287

Published to Oxford Scholarship Online: May 2006

DOI: 10.1093/0199273286.001.0001

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Phase I Research and the Meaning of ‘Prospect of Direct Benefit’

Phase I Research and the Meaning of ‘Prospect of Direct Benefit’

Chapter:
(p.104) 6 Phase I Research and the Meaning of ‘Prospect of Direct Benefit’
Source:
Children in Medical Research
Author(s):

Lainie Friedman Ross (Contributor Webpage)

Publisher:
Oxford University Press
DOI:10.1093/0199273286.003.0007

This chapter examines the issue of whether phase I pediatric oncology trials offer the prospect of direct benefit. Phase I research is carried out to determine toxicity; the possibility of direct benefit is secondary to the objectives of the study. Focusing exclusively on whether phase I trials could be interpreted as offering the prospect of direct benefit fails to acknowledge the moral relevance of the researchers’ intent. If intentions matter, then phase I studies cannot be said to offer the prospect of direct benefit.

Keywords:   direct benefit, pediatric oncology, medical research, pediatric research

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